The term is usually derived from the Latin word gutta or drop. The first person to name the disease was " Randolph of Bocking" in the early 1200s. Which later on given the name of Uric acid in further studies. After a century later there is another scientist named Cappadocian gave a proposal that the gout disease is caused by the toxin in the blood. Although it was first recognized by Egyptians the first clinical description of the disease came from Hippocrates ( 460-370). The scientist has a lot to offer regarding this chronic and debilitating disease. Out of them, the males are affected the most. This is one of the most studied diseases do far with more than millions of people still suffering from the disease until today. Gout was first identified by Egyptians around 2640 BC. Gout is among the oldest recognized diseases with a profound impact on patient quality of life.Antoine van Leeuwenhoek contributed to the field by describing the appearance of uric acid crystals in 1679., (1632-1723)._Natuurkundige_te_Delft_Rijksmuseum_SK-A-957.jpeg
The German chemist Fischer, who won the Nobel Prize in 1902, discovered that purines found in meat, fish and alcohol are responsible for the development of uric acid.Ĭonclusions: It's amazing how physicians describe the same medical condition depending on the knowledge and the technological methods that were available to them. At the end of 19th century the use of agents, such as probenecid, fenofibrate, allopurinol, NSAIDs was discovered to induce uricosuria and resolution of tophi. The term is derived from latin word gutta ( drop), which is drop or flow into the joint causing pain and inflammation caused by uric acid crystals forming within the joint.Īntoni var Leeuwenhock (1632-1723) first described microscopically the appearance of crystals from a gouty tophi.Īlfred Garrod (1819-1907) devised the uric acid threat test, which depended on crystallization of urate on linen thread and could be controlled by lowering intake of purine-rich food. Oribasius (400 CE) mentioned that gout affects the feet, while arthritis affects hands, knees, elbow.ĭominician monk Randolphus of Bocking (1197-1258) named gout podagra. Ruphus of Ephesus ( 1st century) believed that internal organs could become affected by gouty humor and would provoke pulmonary, cerebral and renal failure resulting in death. Galen, six centuries later (215 AD) described tophi as the manifestation of longstanding gout and hyperuricemia lumps of crystallized uric acid under the skin. He also believed that gout occured in post-pubertal male and post-menopausal women. He called gout the "unwalkable disease", the "arthritis of the rich" because of the lifestyle of the rich people including excess food and wine. Hippocrates (460-370 B.C.) recognized gout as the result of an excessive accumulation of one of the four of the bodily humors, phlegm, which affected the joint painfully. Results: The Ancient Egyptians firstly identified uric acid in 2640 B.C. Methods: We studied recent articles related to the history of gout through different periods. The aim of this study is to elucidate how physicians perceived this medical condition through centuries. It is caused by deposition of too much uric acid crystals forming around joints and most often the big toe is affected.
Introduction and Aims: Gout is a medical condition which describes a painful form of arthritis that affects people's joints.
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